Our latest research!
Our latest paper of 2026 is out!
In this collaborative study we established the role of uridine cytidine kinases (UCKs) in the activation of the antiviral nucleoside analogue molnupiravir, opening new avenues to improve this therapy.
Our second paper of 2026 is out!
In this study we wanted understand which dNTP pool imbalances affect SAMHD1 drug resistance activity. We identified IMPDH inhibitors - depleting guanine nucleotides - as one such strategy, offering a potential repurposing approach to improve leukaemia treatment.
Kicking off 2026 with our new publication!
In this study we investigate the allosteric regulation of SAMHD1 and identify antiviral guanine nucleotides as modulators of its activity, offering a new way to control this drug‑metabolising enzyme.
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